Professor Liu's research integrates chemistry and evolution to illuminate and program biology. His group's major research interests include (i) the discovery of therapeutically relevant synthetic molecules using DNA-templated organic synthesis, a technique developed in his laboratory, and Darwinian selection; (ii) the characterization and engineering of genome-editing proteins towards next-generation human therapeutics; and (iii) the laboratory evolution and delivery in vivo of proteins that modify information flow in human cells.